An autoimmune disease is a medical condition in which the body immunity n turns against itself; polyarteritis nodosa (PAN) is one such rare, autoimmune disorder. The pathophysiology of this disease mainly involves inflammation of the small arteries in the body. This affects mostly the skin, joints, peripheral nerves, intestines and kidneys, and causes symptoms such as fever, night sweats, weight loss, muscle and joint pains, and skin ulceration or nodule formation. This is a serious condition, and mortality or morbidity may result from spontaneous bleeding from multiple sites in the body, or due to irreversible damage to the intestines, kidneys, heart or brain.
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